Total Voting Rights and Capital

30 March 2012

Instem plc
("Instem", the "Company" or the "Group")

Total Voting Rights and Capital

In conformity with the Disclosure and Transparency Rules we would like to notify the market of the following:

The Company's issued share capital consists of 11,764,657 ordinary shares with a nominal value of 10p each ('Ordinary Shares'). The Company does not hold any Ordinary Shares in Treasury.

Therefore, the total number of voting rights in the Company is 11,764,657.

The figure of 11,764,657 may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FSA's Disclosure and Transparency Rules.

For further information, please contact:

Instem plc	www.instem.com
Phil Reason, CEO	+44 (0) 1785 825600
Nigel Goldsmith, CFO
N+1 Singer (Nominated Adviser & Broker)	+44 (0) 20 7496 3000
Richard Lindley
Nick Owen
James White
Wallbrook Financial PR	Tel: +44 (0) 20 7933 8000
Paul Cornelius	or instem@walbrookpr.com
Sam Allen
Helen Cresswell
Paul Whittington

About Instem

Instem is a leading supplier of IT applications to the early development healthcare market delivering compelling solutions for data collection, management and analysis across the R&D continuum. Instem applications are in use by customers worldwide, meeting the rapidlyexpanding needs of life science and healthcare organisations for data-driven decision making leading to safer, more effective products.

Instem’s portfolio of software solutions increases client productivity by automating study-related processes while offering the unique ability to generate new knowledge through the extraction and harmonization of actionable scientific information.

Instem supports over 450 clients through full service offices in the United States, United Kingdom and China with additional locations in Japan and India.

To learn more about Instem solutions and its mission, please visit instem.com.